On March 14, 2025, Seledora® Coronary Scoring Balloon Catheter, developed by Mixin Medtech(Suzhou) Co., Ltd., a subsidiary of Kossel Medtech (Suzhou) Co., Ltd., received approval from the National Medical Products Administration (NMPA) for market launch (Registration No. 20253030586). Kossel’s independently developed Octoparms® II Vena Cava Filter has also been approved by the NMPA today (Registration No. 20253130576).
The approval of the Seledora® Coronary Scoring Balloon Catheter marks another breakthrough for Kossel in the full-cycle management of “precise pre-treatment – vascular function restoration” in coronary interventions. Moving forward, Kossel will continue to drive innovation, providing high-quality medical devices to clinical practitioners and developing systematic solutions for coronary interventions.
In modern life, plastic is everywhere, from daily food packaging, to the shell of electronic products, to various parts of car interior, it has brought great convenience to our lives. However, plastic sometimes emits unpleasant odors, which not only affects the user experience, but may also cause practical troubles in some scenarios. Plastic deodorant is the key to solving this problem.
There are many sources of plastic odor. First, the monomers of synthetic plastics are a common source of odor. Take the monomer vinyl chloride of polyvinyl chloride (PVC) as an example. It has a unique odor itself. If the polymerization process is not properly controlled, the residual monomer will make the plastic have an odor. Some plastics made of natural polymers, such as cellulose-based plastics, may also inherit odors from their plant raw materials. Second, various additives added to improve the performance of plastics, such as plasticizers, flame retardants, antioxidants and colorants, may also become odor makers. Third, during long-term use, plastics are degraded by factors such as light, heat, and oxygen, and the polymer chains break, releasing volatile unpleasant substances. For example, polyethylene (PE) and polypropylene (PP) plastics emit a pungent odor when they are oxidatively degraded.
So, how do plastic deodorants work? There are three main ways. The first is the adsorption principle, and the typical representative is the deodorant containing activated carbon. Activated carbon has a huge specific surface area and rich micropores. It can adsorb odor molecules on the surface through van der Waals force, reducing the concentration of odorous substances inside the plastic and in the surrounding air. In food plastic packaging, activated carbon deodorants can effectively absorb the odor emitted by food and prevent cross-flavor. The second is the chemical reaction mechanism. Some deodorants contain compounds that can react with odorous substances.
Plastic deodorants are widely used in many fields. In the packaging industry, whether it is food packaging that needs to ensure that it does not affect the flavor of food, or drug packaging that needs to maintain an odorless state to avoid affecting the quality of drugs and consumer perception, or cosmetic packaging that needs to keep the product aroma undisturbed, plastic deodorants are crucial. In the automotive industry, deodorants can be used to remove the “new car smell” produced by the mixture of plastic parts, adhesives and fabrics in the interior of new cars, and to reduce the odor caused by the thermal degradation of plastic parts in the engine compartment. The electronics industry is also inseparable from it. The plastic shells and insulating parts of devices such as smartphones and laptops can prevent odors from interfering with the user experience, and can also prevent odor substances from corroding or affecting the functions of electronic components.
In short, although plastic deodorants seem inconspicuous, they play an indispensable role in improving the quality of plastic products and optimizing the user experience. As technology continues to advance, it will help plastics better serve our lives.
On March 14, 2025, the Octoparms® II vena cava filter independently developed by Kossel Medtech (Suzhou) Co., Ltd. was approved by the National Drug Administration (NMPA). (registration number is 20253130576). In addition, the Seledora® coronary scoring balloon catheter developed by the subsidiary Mixin Medtech was also approved by the National Medical Products Administration (NMPA) today. (registration number is 20253030586).
Vena Cava Filter
Three core advantages upgraded
The stability upgraded
Retrieval hook is smooth to reduce delivery resistance
Raise and widen the balance arm to improve long-term stability
New anchoring hook design, anti-displacement, anti-penetration
Diamond-shaped filter can effectively block thrombus of 4mm and above
Releasable and interlocking arm design, to achieve controlled release in a transjugular way
Double markers with a space of 30mm, help measure the diameter of the inferior vena cava
The sheath is braided to enhance support and bending resistance and establish a stable path
The sheath end is thread design, anti-shift, easy to approach
The delivery system
Octoparms® vena cava filter, clinically proven, is a domestic umbrella-shaped filter with excellent performance, it has been recognized by nearly 2,000 hospitals in China since its launch, benefiting tens of thousands of patients.
Coming out of the clinic need and serving the clinic need, Octoparms® Ⅱ, an upgrade of the Octoparms® vena cava filter, will be more widely used and accepted for the benefit of more patients
The MiStent coronary drug-eluting stent, an important overseas transformation project of Corecell Medical, has officially entered the Chinese market with two major advantages of “rapid healing and long-lasting efficacy”, providing a new clinical option for PCI surgeries.
This issue will introduce the design story behind the realization of the “long-lasting efficacy” function of the MiStent coronary drug-eluting stent.
1. Encapsulated Sirolimus Crystals
The coating of the MiStent coronary drug-eluting stent is composed of a rapidly bioabsorbable PLGA polymer and sirolimus crystals embedded therein. Sirolimus crystals refer to the close arrangement of individual drug molecules to form a lattice structure, as shown in the figure:
Sirolimus molecules are compressed into a lattice structure
2. Polymer Degradation and Drug Crystal Release
When the PLGA polymer degrades, it softens and detaches from the metal stent platform. Over time, the polymer coating increasingly integrates into the surrounding tissues. The crystalline sirolimus embedded in the polymer also enters the surrounding tissues with it. The PLGA polymer of the MiStent coronary drug-eluting stent completely detaches from the stent within 45 – 60 days and is completely absorbed within 90 days.
Sirolimus crystals are embedded in the surrounding tissues
3. Dissolution of Drug Crystals and Release of Individual Drug Molecules
For individual sirolimus molecules to interact with receptors in arterial tissues, they must first dissociate from the lattice, then diffuse into the intercellular spaces of tissues, and finally pass through the cell membrane to reach the target cells. This process achieves a slow and continuous drug elution effect, and the efficacy can be maintained for up to 9 months, fully covering the coating degradation time, continuously inhibiting the excessive proliferation of vascular smooth muscle, and minimizing the incidence of in-stent restenosis.
As a Component in Deodorant Formulations: Fatty acid powder can be an integral part of PVC deodorant formulations. Some fatty acids, such as lauric acid or stearic acid, possess certain properties that can contribute to odor control. These fatty acids can interact with odor – causing compounds through processes like acid – base reactions or physical adsorption. For example, if the odor in PVC is due to the presence of basic degradation products, the acidic nature of fatty acids can neutralize them. When using a deodorant containing fatty acid powder, it’s essential to ensure proper mixing during the compounding process. Just like other deodorant ingredients, fatty acid powder should be added at the start of the compounding stage. This allows it to blend well with the PVC resin and other additives, enabling it to evenly distribute throughout the matrix and effectively target odor – causing substances. As an Auxiliary Additive:
Fatty acid powder can also be used as an auxiliary additive to enhance the performance of traditional PVC deodorants. It can improve the dispersion of other deodorant components, such as activated carbon or zeolites, in the PVC matrix. When added in appropriate amounts, fatty acid powder reduces the surface tension between the deodorant particles and the PVC resin, promoting better mixing. To use fatty acid powder in this way, it should be added in small, carefully measured quantities. A common starting point could be around 0.1% – 0.5% by weight of the total PVC formulation. Manufacturers need to conduct trial runs with different concentrations to determine the optimal amount that maximizes the dispersion of the main deodorant ingredients without negatively affecting the physical properties of the PVC product. Considerations for Fatty Acid Powder Usage:
The type of fatty acid powder selected matters. Different fatty acids have varying chemical structures and properties, which can impact their effectiveness in odor control and their compatibility with the PVC matrix. For instance, longer – chain fatty acids may have better solubility in certain PVC formulations but may also require more energy to disperse evenly. Additionally, the quality of the fatty acid powder is crucial. Impurities in the powder can potentially react with other components in the PVC system, leading to unwanted side – effects such as discoloration or a decrease in the overall performance of the deodorant. It’s recommended to source high – purity fatty acid powder from reliable suppliers.
As people pay more and more attention to skin care, the cosmetics industry continues to pursue higher quality and more efficient ingredients. As a natural and versatile raw material, fatty acid powder has gradually emerged in the cosmetics field and plays an important role.
1.Emulsification
Among many cosmetics, products such as lotions and creams require the oil phase and the water phase to be evenly mixed to form a stable emulsified system. Fatty acid powder has excellent emulsification properties and can reduce the surface tension of the oil-water interface so that the two are closely combined. For example, in a moisturizing cream, fatty acid powder can help oil and water disperse evenly, making the cream texture more delicate, easy to spread when applied, and improving the feel of use. Moreover, a stable emulsification system helps to extend the shelf life of the product and ensure that the cream will not separate oil and water during storage.
2.Moisturizing
Retaining moisture in the skin is essential for maintaining skin health. The long-chain fatty acids in fatty acid powder can form a thin protective film on the surface of the skin, which can prevent the loss of moisture inside the skin and play a moisturizing role. At the same time, it can also increase the softness and smoothness of the skin, making the skin feel more delicate. For example, in some skin care products suitable for dry skin, fatty acid powder can work synergistically with other moisturizing ingredients to enhance the moisturizing effect and keep the skin moisturized for a long time.
3.Regulating the pH value of the skin
The surface of the skin has a natural weak acidic environment, and the pH value is usually between 4.5 and 6.5. This environment helps to maintain the barrier function and microbial balance of the skin. Fatty acid powder has a certain acid-base regulating ability, which can help cosmetics adjust to a range close to the pH value of the skin and reduce irritation to the skin. For example, adding fatty acid powder to cleansing products can enable the product to better protect the acid-base balance of the skin while cleaning the skin, and avoid damage to the skin barrier caused by excessive cleaning.
MiStent® Sirolimus Eluting Absorbable Polymer Coronary Stent System’s ability to simultaneously offer the advantages of “rapid healing and long-lasting drug efficacy” is attributed to its unique coating process—supercritical fluid coating technology.
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Mistent® coronary drug-eluting stent system, as an important overseas transformation project of Kossel Medical, has officially launched in the Chinese market with two advantages of “fast healing and long efficacy”, providing a new clinical choice for PCI surgery.
This article brings you the design story behind the realization of the “fast healing” function of Mistent®
一、Thin-wall stent design
Thick-wall stent can lead to stent thrombosis: high endothelial shear stress (ESS) at the top of the strut activates platelets; In the lower ESS area downstream of the strut, blood vortex is formed, which increases the concentration of locally activated platelets, delays re-endothelialization, and weakens the production of autogenous anticoagulants
After implantation of thin-wall stents into blood vessels, the physiological ESS was retained, which was conducive to platelet immobilization at the top of the strut, and promoted re-endothelialization and antithrombotic factor production downstream of the strut.
Mistent® uses a 64μm ultra-thin cobalt-chromium stent platform to achieve rapid endothelialization and reduce the risk of acute thrombosis.
Ordinate: stent strut thickness μm
二、Absorbable polymer coating
The coating of the Mistent® consists of a rapidly bioabsorbable PLGA polymer and embedded Sirolimus crystals
Under the dual action of polymer embedding and drug crystal binding, Mistent® implantation in blood vessels did not cause drug sudden release at the initial stage and did not delay vascular endothelialization
Endothelialization was achieved after 3 days of stent implantation
Endothelium was uniformly covered after 30 days of stent implantation
K&G Machinery, a leading manufacturer and supplier of industrial equipment, is proud to announce the expansion of its product line with a comprehensive range of Stainless Steel Camlock Couplings. Designed to meet the diverse needs of various industries, these couplings are available in multiple types, including Type A, Type B, Type C, Type D, Type E, Type F, Type DC, and Type DP, ensuring a perfect fit for every application.
Unmatched Durability and Performance
Crafted from premium-grade stainless steel, K&G Machinery’s Camlock Couplings are built to withstand the harshest industrial environments. Whether it’s for chemical processing, oil and gas, food and beverage, or water treatment applications, these couplings offer exceptional resistance to corrosion, high temperatures, and wear, ensuring long-lasting performance and reliability.
This extensive selection allows customers to find the exact coupling type needed for their unique operational demands, ensuring seamless connections and efficient fluid transfer.
Commitment to Quality and Innovation
At K&G Machinery, quality is at the core of everything we do. Our Stainless Steel Camlock Couplings are manufactured using state-of-the-art technology and undergo rigorous quality control processes to meet international standards. We are committed to providing our customers with products that not only meet but exceed their expectations.
Custom Solutions Available
Understanding that every industry has unique challenges, K&G Machinery also offers custom solutions tailored to specific requirements. Our team of experts is always ready to collaborate with clients to develop bespoke coupling solutions that address their specific needs.
Global Reach, Local Support
With a robust distribution network and a dedicated customer support team, K&G Machinery ensures that clients worldwide have access to our high-quality products and exceptional service. Whether you’re looking for standard or custom solutions, our team is here to assist you every step of the way.
About K&G Machinery
K&G Machinery has created this website specifically dedicated to all your cam lock fitting needs. we supply quality camlock fittings and camlock couplings. We pride ourselves in excellent customer service and unbeatable prices. From cam and groove fittings, to ball valves and gaskets, we supply high quality products for you in an efficient and timely manner. We stock cam and groove couplings in various configurations and materials including stainless steel, aluminum, brass and polypropylene.Hose fittings from K&G are designed for use with their entire range of rubber hoses,PVC hoses and composite hoses. They have proven themselves in a wide range of industrial and mining applications and are manufactured to cater for all bore sizes across our comprehensive range of industrial and mining hoses. This ensures that we have hose fittings for your requirements.
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